The LSU Tigers kick off the Brian Kelly era when they take on the Florida State Seminoles on Sunday. FSU leads the all-time series 7-2. Kick off from Caesars Superdome in New Orleans is set for 7:30 p.m. ET. LSU is favored by 4-points at Caesars Sportsbook, while the over/under is set at 50.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Florida State vs. LSU picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

The model knows expectations are high for the Tigers, who want to build their way to an eventual fourth national championship. Arizona State transfer Jayden Daniels is expected to take over at quarterback. Last season at ASU, Daniels saw action in 13 games for the Sun Devils, including a 20-13 loss to Wisconsin in the Las Vegas Bowl. Daniels finished the season by completing 197 of 301 passes (65.4 percent) for 2,380 yards and 10 touchdowns with 10 interceptions. In his three-year career at Arizona State, he completed 451 of 723 passes (62.4 percent) for 6,024 yards and 32 touchdowns with 13 interceptions.

The model also knows the Seminoles appear to have a solid rushing attack. In the opener, running backs Treshaun Ward (127), Trey Benson (105) and Lawrence Toafili (101) all broke the 100-yard rushing mark. It was the first time in Florida State history that three players ran for 100 or more yards in the same game. FSU finished with 406 total yards, including 232 passing. It was the first 400-200 game for the Seminoles since 1995, when they accomplished that mark against Wake Forest.

Now, it has set its sights on Florida State vs. LSU. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 60% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

So who wins Florida State vs. LSU? And which side of the spread hits in well over 60% of simulations? Join SportsLine now to find out, all from the model that has crushed its top-rated college football picks against the spread!