The No. 15 Clemson Tigers will aim for their fourth consecutive victory when they face the Florida State Seminoles in a road game on Saturday night. Clemson opened the season with a blowout loss to Georgia, but it has responded with three straight decisive wins. Florida State has lost four of its first five games during a disastrous campaign, including a 42-16 setback at SMU last week.  

Kickoff is set for 7 p.m. ET on Saturday at Bobby Bowden Field at Doak Campbell Stadium. Clemson is favored by 14.5 points in the latest Florida State vs. Clemson odds, while the over/under is 46.5 points, per SportsLine consensus. Before entering any Clemson vs. Florida State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen STRONG returns.

The model has simulated Florida State vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations.

So who wins Florida State vs. Clemson, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!