The 2021-22 UEFA Europa League Round of 16 begins on Wednesday when Porto hosts Lyon in a first-leg matchup. Lyon advanced to this stage after winning its group, while Porto defeated Lazio in a knockout playoff round to reach the Round of 16. The second leg will then take place on March 17. You can stream Wednesday's matchup on Paramount+. 

Kick-off is set for 12:45 p.m. ET at Estádio do Dragão in Porto, Portugal. Caesars Sportsbook has Porto listed as the +101 favorite (risk $100 to win $101) on the 90-minute money line while Lyon is a +275 underdog in the latest Lyon vs. Porto odds. A draw is priced at +235 and the over-under is 2.5 goals. Wednesday's match will be streamed live on Paramount+ with their MUST-HAVE Premium plan.

Paramount+ now has levels of membership so you can watch the hottest soccer matchups worldwide and much more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream, including plenty of sports like Champions League, Italian Serie A, college hoops, and the PGA Tour, with no ads, on demand and the ability to download episodes for offline viewing. Plus, watch the highly-anticipated series Halo, Picard, 1883, and more. Both plans come with a free week to start and include soccer matches. So sign up now here.

Before making any Porto vs. Lyon picks, you MUST see what renowned soccer bettor Jon Eimer has to say. 

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, Eimer has covered the English Premier League, Serie A, the FA Cup and much more. The Indiana-based handicapper compiled a winning record of 260-133-1 with over 90 units of profit for his community on various platforms over a recent two-month stretch.

Now, Eimer has taken a close look at Lyon vs. Porto, and we can tell you he is backing over 2.5 goals at -145 odds. He's also locked in two other best bets. You ABSOLUTELY need to see his picks and analysis before making any selections of your own. And don't forget to stream NOW on Paramount+!

Who wins Porto vs. Lyon? And where does all the betting value lie? ... Join SportsLine now to see Jon Eimer's best bets for Lyon vs. Porto, all from the soccer insider who's compiled a winning record of 260-133-1 over a recent two-month stretch!