The Eastern Michigan Eagles will take on the Buffalo Bulls at noon ET on Saturday at Rynearson Stadium on CBS Sports Network. Eastern Michigan pulled off a huge upset last week, taking down Arizona State as a 20.5-point underdog. The Eagles are favored by 6 points in the latest Eastern Michigan vs. Buffalo odds from Caesars Sportsbook, while the over/under is set at 60.5. 

Before you make any Buffalo vs. Eastern Michigan picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Eastern Michigan vs. Buffalo 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Eastern Michigan vs. Buffalo? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!