The No. 11 Notre Dame Fighting Irish (4-1) travel to Durham, N.C. to take on the No. 17 Duke Blue Devils (4-0) on Saturday. Kickoff is at 7:30 p.m. ET. The Irish are looking to bounce back from a heart-breaking 17-14 last second loss to Ohio State. Duke is looking to improve to 5-0 after throttling UConn 41-7 last Saturday behind a huge performance from quarterback Riley Leonard. Notre looks to extend its winning streak in regular season games against ACC opponents to 30. Duke and Notre Dame last played in 2020 with the Irish winning 27-13.

The Irish are 5.5-point favorites in the latest Duke vs. Notre Dame odds via SportsLine consensus, while the over/under for total points scored is 53. Notre Dame is the -217 favorite on the money line, while Duke is the +178 underdog (see up-to-date odds for every game this week on our college football odds page).

Before you make any Notre Dame vs. Duke picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his football picks for SportsLine in 2023, going 9-2 on his best bets up to this point of the season. Anyone who has followed his picks is WAY UP!

Kaylor knows that Notre Dame is coming off a major letdown in its last second loss to Ohio State last Saturday and could be dealing with a hangover from that game. He also knows that the Irish have a heavy veteran presence in their locker room, led by transfer quarterback Sam Hartman, and have won 29 consecutive regular season games against ACC opponents.

Kaylor, however, factored in that like Notre Dame, Duke is an experienced team with a talented quarterback of their own in Riley Leonard. The Blue Devils are elite on the defensive side of the ball, giving up only 8.8 points per game. This team shocked the college football world in Week 1, dominating Clemson 28-7.

Now, Kaylor has locked in a confident against-the-spread pick for Notre Dame vs. Duke. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Notre Dame vs. Duke in at Brooks Field at Wallace Wade Stadium on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Duke vs. Notre Dame spread to jump on, all from the expert who is on a 9-2 roll this season, and find out!