No. 9 Duke will try to avoid losing consecutive games for the first time since early December when it hosts Notre Dame in an ACC matchup. Tipoff is set for 9 p.m. ET on Wednesday at Cameron Indoor Stadium. Duke is favored by 17 points in the latest Duke vs. Notre Dame odds, while the over/under is 134 points, per SportsLine consensus. 

Before entering any Notre Dame vs. Duke picks, you NEED to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 14 of the 2023-24 season on a 124-82 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 20-9 start on top-rated spread picks this season. Anyone following has seen HUGE returns!

The model has simulated Duke vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

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