The No. 3 seed Creighton Bluejays and the No. 2 seed Tennessee Volunteers meet in the Sweet 16 round of the Midwest Region with a trip to the Elite Eight on the line. The Bluejays needed two overtime periods to get past Oregon in the second round, winning 86-73. The Vols struggled with Texas in their second round matchup, but were able to advance with a 62-58 win. The winner of this game will take on the winner of Purdue vs. Gonzaga in the Midwest Region final. 

Tipoff is scheduled for 10:09 p.m. ET at Little Caesars Arena in Detroit. The Vols are 3.5-point favorites in the latest Creighton vs. Tennessee odds via SportsLine consensus, while the over/under is 146 points (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Tennessee vs. Creighton picks, you need to check out the college basketball predictions and betting advice from the SportsLine expert Jimmie Kaylor.

Kaylor is a betting and DFS expert for SportsLine, who has covered college sports and the NFL for close to a decade as a member of the Pro Football Writers of America. His background as a former high level athlete -- he was a Division-I All-American and professional athlete -- gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college basketball landscape and has been cashing in big for SportsLine members for the last two years. 

Kaylor enters the Sweet 16 round on a 22-10 run overall on his college basketball picks, with a 7-2 record on 2024 NCAA Tournament picks for SportsLine. He is up 11.05 units, returning a profit of $1,105 for $100 bettors. Anyone who has followed his picks is way up!

Now, Kaylor has locked in a confident against-the-spread pick for Tennessee vs. Creighton in the Sweet 16 round of the 2024 NCAA Tournament. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own. 

Who wins Tennessee vs. Creighton, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the proven expert who has been cashing BIG for SportsLine members for the last two years!