The Washington Commanders are set to host the Arizona Cardinals in a Week 1 matchup on Sunday. The Commanders enter their fourth season under head coach Ron Rivera, and are coming off an 8-8-1 record in 2022. Sam Howell is set to take over as the team's full time starting quarterback in 2023. The Cardinals are in the midst of a rebuilding project after finishing with a 4-13 record in 2022. Jonathan Gannon was hired as the team's new head coach, and his starting quarterback to open the season will be newly acquired Joshua Dobbs. 

Kickoff from FedEx Field is scheduled for 1 p.m. ET. Washington is a 7-point favorite and the over/under for total points scored is 38 in the latest Commanders vs. Cardinals odds.

Before making any Cardinals vs. Commanders picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has set its sights on Cardinals vs. Commanders. We can tell you the model is leaning Over on the point total, and it also says one side of the spread cashes in well over 54% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Cardinals vs. Commanders in Week 1 of the 2023 NFL season? And which side of the spread cashes well over 50% of the time? ... Join SportsLine right now to find out which side of the Commanders vs. Cardinals spread is a MUST-BACK, all from the model on a 163-113 roll on NFL picks!