The Washington Commanders and the San Francisco 49ers are set to square off in an NFC battle at 1:00 p.m. ET on December 31st at FedEx Field. Washington is 4-11 overall and 1-5 at home, while San Francisco is 11-4 overall and 6-2 on the road. The 49ers are coming off a 33-19 loss to the Baltimore Ravens, but still hold the No. 1 seed in the NFC Playoffs. The Commanders are looking to snap a six-game losing streak after falling 30-28 to the New York Jets in Week 16.

Kickoff at FedEx Field is scheduled for 1 p.m. ET. The 49ers are favored by 14 points in the latest Commanders vs. 49ers odds, and the over/under is 49.5 points. Before locking in any Commanders vs. 49ers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has simulated Commanders vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. 

So who wins Commanders vs. 49ers, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!