The Anthony Richardson era gets underway for the Indianapolis Colts when they host Trevor Lawrence and the Jacksonville Jaguars in an AFC South rivalry game on the Week 1 NFL schedule. Richardson, the No. 4 overall pick in the 2023 NFL Draft, will be making his regular season debut for a young, rebuilding Colts team. Lawrence is set to embark on his third professional season and will be leading a talented Jaguars team that has championship aspirations in 2023. 

Kickoff from Lucas Oil Stadium in Indianapolis is scheduled for 1 p.m. ET. Jacksonville is a 4.5-point favorite and the over/under for total points scored is 46 points in the latest Jaguars vs. Colts odds.

Before making any Colts vs. Jaguars picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has set its sights on Jaguars vs. Colts. We can tell you the model is leaning Under on the point total, and it also says one side of the spread cashes in over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Jaguars vs. Colts in Week 1 of the 2023 NFL season? And which side of the spread cashes over 50% of the time? ... Join SportsLine right now to find out which side of the Colts vs. Jaguars spread is a MUST-BACK, all from the model on a 163-113 roll on NFL picks!