AFC South contenders will meet up in Week 6 when the Indianapolis Colts (2-2-1) and Jacksonville Jaguars (2-3) battle in Indianapolis on Sunday on Paramount+. Kickoff for Sunday's game from Lucas Oil Stadium is set for 1 p.m. ET. The Colts are 1.5-point favorites in the latest Colts vs. Jaguars odds from Caesars Sportsbook, and the over/under for total points is 41. 

Sunday's showdown will be televised on CBS and streamed live in select markets on Paramount+ with their MUST-HAVE Premium plan. Plus, you can watch games on ANY device and get 30 days free with the promo code NFLONCBS!

You can catch all your local NFL on CBS games on Paramount+, which now has two plans. The Essential Plan costs $4.99 per month to access Paramount's catalog of movies and TV shows with limited advertisements, plus your live local NFL games, international soccer and more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream with no ads, on demand and the ability to download episodes for offline viewing. Before the end of October, you can get 30 days free with the promo code NFLONCBS, so sign up now here.

Before making any Colts vs. Jaguars picks or any other NFL predictions, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated Colts vs. Jags 10,000 times and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread hits over 50% of the time! You ABSOLUTELY need to see it before locking in your own picks. And don't forget you may be able to stream the game on Paramount+ on ANY DEVICE!

Who wins Jaguars vs. Colts? And which side of the spread hits over 50% of the time? ... Join SportsLine right now to see which side of the Colts vs. Jaguars spread to jump on, all from the model that has crushed its NFL picks!