The Indianapolis Colts (4-5) host the Buffalo Bills (7-2) in an NFL Week 10 battle on CBS and Paramount+. Kickoff from Lucas Oil Stadium in Indianapolis is 1 p.m. ET. The Bills are 4.5-point favorites in the latest Colts vs. Bills odds via SportsLine consensus, and the over/under for total points scored is 46.5. The Bills are -227 money line favorites (risk $227 to win $100), while the Colts are +187 underdogs. You may be able to stream Sunday's game live on Paramount+, which you can now try free for the first seven days when you sign up here.

Paramount+ is the only place to watch every minute of every NFL on CBS game this season. A subscription also gives you access to other sports content including the UEFA Champions League and Europa League, NWSL, Serie A, and countless movies and shows. You can now get a free 7-day trial, so sign up right here.     

Before making any Colts vs. Bills picks or any other NFL predictions, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2024 NFL season on an incredible 14-7 hot streak on top-rated NFL picks this year. Longer term, it is on a 195-136 roll on top-rated NFL picks that dates back to the 2017 season and a 49-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

Now, it has simulated Colts vs. Bills 10,000 times and the results are in. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in over 50% of simulations! You ABSOLUTELY need to see it before locking in your own picks. And don't forget you may be able to stream the game on Paramount+ on ANY DEVICE!

Who wins Bills vs. Colts, and which side of the spread hits over 50% of the time? ... Join SportsLine right now to find out which side of the Bills vs. Colts spread is a MUST-BACK, all from the model on a 195-136 roll on NFL picks!