Colorado and TCU will meet for the first time ever on Friday, with neither team revealing who their starting quarterback will be. The Buffaloes came in fourth in the Pac-12 South last year, while TCU finished seventh in the Big 12. The Horned Frogs are favored by 13.5 points in the latest Colorado vs. TCU odds from Caesars Sportsbook, while the over/under is set at 58.5.

Before you make any TCU vs. Colorado picks, you'll want to see the college football predictions from the SportsLine Projection Model. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Colorado vs. TCU 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in in over 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Colorado vs. TCU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.