After a thrilling Week 1 of college football that saw six ranked teams get upset, the Week 2 schedule is also loaded with several inter-conference showdowns. In the marquee matchup, Ohio State is favored by 14 points against Oregon in the latest Week 2 college football odds from Caesars Sportsbook. Other highly-anticipated games include Michigan at -6.5 against Washington, Iowa State at -4.5 vs. Iowa and Texas at -7 against Arkansas.

Before making any college football picks for Week 2, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 2 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 2: Iowa (+4.5) stays within the spread against Iowa State in that battle for the Cy-Hawk Trophy. The Hawkeyes get the cover in well over 50 percent of simulations. 

Another prediction: Michigan (-6.5) covers against Washington in a Big Ten vs. Pac-12 matchup. The Wolverines cover in well over 60 percent of simulations, while the over (50.5) hits well over 50 percent of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it is calling for multiple must-see upsets. You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which favorites go down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned over $3,600 in profit on top-rated ATS picks over the past five-plus seasons!