Week 6 of the college football schedule features just one ranked vs. ranked matchup, with No. 9 Missouri visiting No. 25 Texas A&M (A&M is tied for the 25th spot with UNLV). That being said, there's still plenty of interesting games on tap. Among them is No. 10 Michigan visiting Washington for what is now a Big Ten matchup. The Huskies are something of an unlucky 3-2, while the reigning champions are dealing with instability at quarterback. Washington is a 1.5-point home favorite (see college football odds here)

Other notable Week 6 matchups on Saturday include No. 12 Ole Miss at South Carolina (+9.5), Rutgers at Nebraska (-7), and No. 4 Tennessee at Arkansas (+14). Before you make any Week 6 college football predictions, be sure to check out the Week 6 college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

Over the past two college football seasons, Casale is 122-92-5 (57%) overall and 26-8 (76.4%) in bowl games -- all publicly documented. Just last week, Casale advised SportsLine members to back Colorado to go over its team total of 22.5. Deion Sanders' Buffaloes cruised past that number with a 48-21 thumping of UCF.6

Now, he's turned his attention to the 2024 Week 6 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

We can tell you Casale is backing Stanford (+7.5) to cover against Virginia Tech. "Stanford lost to Clemson 40-14, but the Cardinal have been competitive in every other game this season." Casale told SportsLine. 

Casale has also found two other college football picks he loves, including backing an underdog he thinks will cover and potentially win outright! You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 6 in the 2024 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!