Following a wild first two rounds of the 2021 NCAA Tournament that saw contenders like Illinois and Ohio State go home early, March Madness 2021 resumes with the Sweet 16 starting on Saturday. 

With eight more 2021 NCAA Tournament games now on the odds board at William Hill Sportsbook (see the latest lines for each game on our college basketball odds page), you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated every 2021 NCAA Tournament game 10,000 times and revealed its point-spread selections and over-under picks for every single Sweet 16 contest.

We can tell you the model found value on No. 11 UCLA (+5.5) covering against No. 2 Alabama in the East Region. The model says the Bruins cover well over 50 percent of the time, while the Over (142.5) hits well over 60 percent of the time. 

The model has made the call on every other game on the 2021 NCAA Tournament Sweet 16 schedule, and it says there's a No. 1 seed that gets a HUGE scare in the Sweet 16! You ABSOLUTELY need to see who it is before locking in any college basketball picks.

Who should you bet on int the 2021 NCAA Tournament Sweet 16 games? And which underdog is a MUST-BACK? ... Join SportsLine right now to find out which side of the spread you should be all over in each Sweet 16 matchup, all from the model up $2,200 on its top-rated college basketball picks over the past four-plus seasons!