The Clemson Tigers take on the Syracuse Orange at Carrier Dome at 7 p.m. ET on Friday. Clemson is favored by 13.5 points at Caesars Sportsbook, while the Over-Under is set at 43.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Clemson vs. Syracuse picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Clemson is a tremendous defensive team. The Tigers lead the ACC in scoring defense, giving up only 12.2 points per game, and they also rank No. 2 in total defense. Clemson is a top-five group in the conference against both the pass and the run, and the Tigers are allowing an ACC-leading 5.8 yards per pass attempt this season. Clemson yields only 2.7 yards per carry to opposing offenses, and the Tigers still have enough talent offensively to inspire confidence. 

The model also knows Syracuse has been dominant in the running game this season. The Orange lead the ACC in rushing offense, generating more than 240 yards per game, and sophomore quarterback Garrett Shrader rushed for 178 yards in the team's last game against Wake Forest. Freshman running back Sean Tucker is also excelling this season, rushing for 791 yards and nine touchdowns, with more than 200 receiving yards to complement a well-rounded profile.

Now, it has set its sights on Clemson vs. Syracuse. We can tell you the model is leaning under the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Clemson vs. Syracuse? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Clemson vs. Syracuse spread you should be all over Friday, all from the model on a roll on college football picks!