Two of the premier programs in the ACC are set to square off at noon ET on Saturday when the Clemson Tigers host the No. 4 Florida State Seminoles at Memorial Stadium. Clemson (2-1) is looking to build off back-to-back blowout wins over Charleston Southern and Florida Atlantic, while Florida State looks to stay undefeated after narrowly escaping Boston College 31-29. The Seminoles are 2-point favorites in the latest Clemson vs. Florida State odds, while the over/under for total points scored is 55 (see up-to-date odds for every game this week on our college football odds page). FSU quarterback Jordan Travis, who was banged up against Boston College, will play without limitations.

Before you make any Clemson vs. Florida State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has gotten off to a hot start in 2023, going 4-1 in his football picks for SportsLine. Anyone who has followed his picks is WAY UP.

Kaylor knows that Florida State has their sights set on winning their first ACC title since 2014 and earning a trip to the College Football Playoff. Quarterback Jordan Travis got banged up against Boston College, but remains one of the top contenders to win the 2023 Heisman Trophy.

Kaylor also knows that Clemson has won seven straight matchups against Florida State. After suffering a surprising 28-7 loss to Duke in their season opener, Clemson has gone on to notch a pair of blowout victories over Charleston Southern and Florida Atlantic.  The Tigers can't afford another loss if they want to keep their College Football Playoff hopes alive.

Now, Kaylor has locked in a confident against-the-spread pick for Clemson vs. Florida State. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Clemson vs. Florida State on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Florida State vs. Clemson spread to jump on, all from the expert who is on a 4-1 roll on his football best bets for SportsLine!