The Cincinnati Bearcats will take on the Indiana Hoosiers at 3:30 p.m. ET on Saturday at Nippert Stadium. Indiana has a chance to improve to 4-0 after winning a trio of home games to open the season. The Bearcats are favored by 16.5 points in the latest Cincinnati vs. Indiana odds from Caesars Sportsbook, while the over/under is set at 57. 

Before you make any Indiana vs. Cincinnati picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Cincinnati vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Cincinnati vs. Indiana? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.