On Saturday, the No. 8 Cincinnati Bearcats (2-0) will take on the Indiana Hoosiers (1-1) at Memorial Stadium at noon ET. Cincinnati is a 3.5-point favorite in the latest Cincinnati vs. Indiana odds from Caesars Sportsbook, while the Over/Under for total points scored is 50. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you make any Cincinnati vs. Indiana picks and college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of more than $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Cincinnati won its first two games by 35 points and has looked like one of the most dominant teams in college football. Desmond Ridder has provided solid play at quarterback, while Jerome Ford has been an absolute stud in the backfield. Ford has rushed cross the century mark in rushing yards twice to rack up four rushing scores on 30 carries. Indiana's Michael Pennix Jr. bounced back from throwing three picks against No. 5 Iowa by throwing for two scores and rushing for another in a blowout win against Murray State.

Now the model has simulated Cincinnati vs. Indiana 10,000 times, and the results are in. We can tell you that the model is leaning Over on the total, and it has generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the battle between Cincinnati and Indiana? And which side of the spread is hitting in well over 50 percent of the simulations? ... Join SportsLine right now to see which side of the Cincinnati vs. Indiana spread you need to jump on Saturday, all from the computer model that has crushed its college football picks!