The Charlotte 49ers open Conference USA play on Friday when they host the Middle Tennessee Blue Raiders at Jerry Richardson Stadium in Charlotte, N.C. Kickoff is 6:30 p.m. ET. The 49ers are three-point favorites in the latest Charlotte vs. Middle Tennessee odds from Caesars Sportsbook, while the Over/Under for total points scored is 56. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you make any MTSU vs. Charlotte picks and college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Charlotte will be facing a Middle Tennessee team that is undergoing a change at quarterback. On Sunday Bailey Hockman, who started the first three games of the season, informed coach Rick Stockstill that he did not want to play football any longer and wanted to leave the team. For the season, Hockman was 41-of-66 for 463 yards with four touchdowns and two interceptions. He will be replaced by junior Chase Cunningham.

On the other side of the ball, Middle Tennessee faces a Charlotte defense that has struggled to stop the run this season. The 49ers are allowing a whopping 258.0 rushing yards per game; just three teams give up more.

Now the model has simulated Charlotte vs. Middle Tennessee 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it has generated a point-spread pick that is hitting in 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the battle between Charlotte and Middle Tennessee? And which side of the spread hits in 60 percent of simulations? ... Join SportsLine right now to see which side of the Middle Tennessee vs. Charlotte spread you need to jump on Friday, all from the computer model that has crushed its college football picks!