The 2021 Shriners Children's Charleston Classic tips off Thursday, with former tournament champions the Clemson Tigers (3-0) and Temple Owls (1-1) facing off in the second game of the day. Clemson won the inaugural tournament in 2008, while Temple was the 2017 champion.   

Tipoff is set for 4:30 p.m. ET at TD Arena in Charleston, S.C. The Tigers are five-point favorites in the latest Clemson vs. Temple college basketball odds from Caesars Sportsbook, while the Over-Under is set at 133. 

Before you make any Clemson vs. Temple picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model. 

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model has figured in that the Tigers have the more well-rounded scoring, with four players averaging double figures and all five starters hitting double digits in Monday's 93-70 rout of Bryant. Forwards Hunter Tyson (15.3 ppg, 5.7 rpg) and PJ Hall (14, seven) both can score and hit the boards hard. They join a strong backcourt that features Al-Amir Dawes (15 ppg), David Collins (10.3) and Nick Honor (9.7).    

The simulations also have taken into account the star power of Owls guard Khalif Battle, who seems to top 20 points at will. He had 22 in the opener then put up 26 against USC on Saturday, hitting five 3-pointers in a valiant comeback attempt. The Owls cut the lead from 23 points down to four but came up short in the 76-71 loss. Damian Dunn, one of the AAC's top newcomers last season, is averaging 13 points.   

Now, the model has set its sights on Thursday's Clemson vs. Temple matchup. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins the Clemson vs. Temple matchup on Thursday afternoon? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Temple vs. Clemson spread you should be all over Thursday, all from the model on a roll on college basketball picks!