The Virginia Tech Hokies host the Duke Blue Devils on Friday night. Kickoff is set for 7 p.m. ET. The Hokies are 2.5-point favorites and the over-under for total points scored is 52 in the latest Duke vs. Virginia Tech odds. 

Before you make any Duke vs. Virginia Tech picks, you need to hear what SportsLine senior analyst Josh Nagel has to say. A Nevada-based handicapper with more than 20 years of experience in the sports wagering industry, Nagel was SportsLIne's top college football analyst last season.

What's more, he has had a particularly keen eye for these ACC programs, posting an epic record of 9-2 on against the spread picks involving Duke or Virginia Tech over the past two seasons! Anyone who has followed him is WAY UP!

Now, Nagel has made his picks for Duke vs. Virginia Tech. We can tell you he's leaning Over, but he also has isolated a critical x-factor that has him going BIG on one side of the spread! You ABSOLUTELY need to see what it is before locking in any picks of your own. 

Who wins Duke vs. Virginia Tech? And which critical x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Duke vs. Virginia Tech spread to back on Friday, all from the seasoned expert who has hit 82 percent of his picks involving these teams!