The St. Louis Cardinals and Pittsburgh Pirates play the second game of their four-game series when the NL Central rivals collide on Saturday at Busch Stadium in St. Louis. Miles Mikolas (2-3, 4.23 ERA last season) will start for St. Louis; he will face Pittsburgh's Mitch Keller (5-11, 6.17). First pitch is set for 2:15 p.m. ET. 

St. Louis is the -170 moneyline favorite in the latest Cardinals vs. Pirates odds from Caesars Sportsbook, while Pittsburgh is a +150 underdog. The Over/Under for total runs scored is eight. (See the latest lines for every game on our MLB odds page.)

Before making any Pirates vs. Cardinals picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB moneyline picks in 2021, returning more than $700 for $100 players. Anyone following it has seen HUGE returns.

The model knows that St. Louis looks as if it has picked up where it left off last season. Going back to last year, the Cardinals have won 22 of their last 26 games (excluding spring training games). That's the best record in baseball over that stretch by far.

The model also knows that Pittsburgh's Bryan Reynolds is poised for another standout season. Last year the 27-year-old outfielder hit .302/.390/.522 with 24 home runs and 90 RBI during an All-Star season. He also tied for the major league lead with eight triples.

Now, the model has set its sights on Cardinals vs. Pirates. We can tell you it is leaning Over the total, projecting 8.9 total runs, and it also says one side of the moneyline has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cardinals vs. Pirates? And which side of the moneyline has all the value? ... Join SportsLine right now to find out which side of the Pirates vs. Cardinals moneyline you should be all over on Saturday, all from the model that went 209-178 on top-rated MLB moneyline picks in 2021!