The Arizona Cardinals host the Detroit Lions in an NFC showdown on Sunday afternoon. The Cardinals (1-1) defeated the Rams 41-10 in a dominating performance, while the Lions (1-1) lost at home to the Buccaneers, 20-16. Detroit is 4-0-1 in the last five meetings including a 30-12 victory in their most recent matchup in 2021. 

Kickoff from State Farm Stadium is set for 4:25 p.m. ET. Detroit is a 3-point favorite in the latest Cardinals vs. Lions odds, while the over/under for total points is 51.5. The Lions are -149 money-line favorites (risk $149 to win $100). Before making any Detroit vs. Arizona picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated Cardinals vs. Lions 10,000 times and the results are in. We can tell you the model is leaning Over on the total. It also says one side of the spread cashes in more than 50% of simulations! You ABSOLUTELY need to see what it is before locking in any NFL picks of your own!

Who wins Lions vs. Cardinals, and which side of the spread cashes in over 50% of simulations? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!