The Arizona Cardinals will take on the Philadelphia Eagles at 4:25 p.m. ET on Sunday at State Farm Stadium. The Eagles are the lone unbeaten team remaining in the NFL following their 29-21 win over Jacksonville last week. They are favored by 5.5 points in the latest Cardinals vs. Eagles odds from Caesars Sportsbook, while the over/under is set at 48.5. 

Before you make any Eagles vs. Cardinals picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated Cardinals vs. Eagles 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Cardinals vs. Eagles? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.