The BYU Cougars will take on the Wyoming Cowboys at 10:15 p.m. ET on Saturday at LaVell Edwards Stadium in Provo, UT. The Cougars are 2-1 overall and 1-0 at home, while Wyoming is 3-1 overall and 0-1 on the road. BYU enters off a blowout road loss to Oregon while Wyoming upset Air Force as a double-digit underdog last week. The Cougars are favored by 22 points in the latest BYU vs. Wyoming odds from Caesars Sportsbook, and the over/under is set at 50.

Before you make any Wyoming vs. BYU picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

Now, it has simulated BYU vs. Wyoming 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in over 70% of simulations. You absolutely need to see it before locking in your own picks.

So who wins BYU vs. Wyoming? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.