There's a reason the Bills are the oddsmakers' preseason favorite to win the Super Bowl. Had the overtime coin toss in Kansas City gone the other way in the Divisional Round, it very well could've been Josh Allen and company hoisting the Lombardi Trophy. Having added potential impact pieces, rookie running back James Cook, veteran wide receiver Jamison Crowder, and two-time Super Bowl champion linebacker Von Miller, Sean McDermott's team is absolutely loaded.

Bills fans have never gotten the chance to celebrate a Super Bowl championship but this is easily their best chance since the early 90's. The schedule is a bit tricky though; potentially seven games will be played on non-Sundays, including being the only team showcased three times on Thursdays. Four of their first six games are on the road before a bye week and a home date against Aaron Rodgers' Packers. From Week 8 forward, Buffalo should be favored in every game with the possible exception of at New England (Week 13) and at Cincinnati (Week 17).

The over 11.5 wins for a preseason Super Bowl favorite seems mouthwatering. Assuming Josh Allen remains upright and healthy, it's hard to see Buffalo not reeling off a six-game (or higher) winning streak at some point during the season. While the AFC and Super Bowl odds seem fair, only those with a super strong conviction can play the Bills with a straight wager at those low odds. It might be worth saving the AFC and Super Bowl bets until the beginning of the postseason when they likely shouldn't be that much lower.

• More NFL futures: SportsLine Projection Model's best bets

Below, you'll find the Buffalo Bills 2022 schedule, win total and more futures odds from Caesars Sportsbook, followed by picks from top SportsLine NFL analysts Larry Hartstein, R.J. White, and Alex Selesnick. You'll also find three bets favored by the SportsLine Projection Model.

Entering the 2022 NFL season, Larry is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 ATS. He went 68-50 ATS (58 percent) and 8-3 on moneyline plays last season for a profit of $1,552. Over the past seven years, R.J.'s SuperContest picks are 329-250-21 (56.8 percent) and he consistently crushes the NFL: He went 445-378-24 on ATS picks from 2017-21, returning $2,542 to $100 players as SportsLine's No. 1 NFL expert in against the spread picks. Selesnick (aka PropStarz) specializes in MLB, NFL and NBA prop betting, where he implements a combination of research, statistical analysis and mathematical modeling to deliver profitable long-term results. 

Buffalo Bills 2022 schedule

Week 1: at Los Angeles Rams (TNF)
Week 2: vs. Tennessee (MNF)
Week 3: at Miami
Week 4: at Baltimore
Week 5: vs. Pittsburgh
Week 6: at Kansas City
Week 7: BYE
Week 8: vs. Green Bay (SNF)
Week 9: at New York Jets
Week 10: vs. Minnesota
Week 11: vs. Cleveland
Week 12: at Detroit (Thanksgiving)
Week 13: at New England (THU)
Week 14: vs. New York Jets
Week 15: vs. Miami (SAT or SUN)
Week 16: at Chicago (SAT)
Week 17: at Cincinnati (MNF)
Week 18: vs. New England

Buffalo Bills 2022 futures odds

Win Total Over: 11.5 (-140)
Win Total Under: 11.5 (+120)

Make Playoffs: -600
Miss Playoffs: +425

Win Division: -220
Win Conference: +350
Win Super Bowl: +650

So will the Bills go over or under their win total for the 2022 season? And what other futures bets are worth making? ... Join SportsLine right now to see Larry Hartstein and R.J. White's Buffalo Bills 2022 futures picks, all from the acclaimed experts who have crushed the NFL for years!