The Denver Broncos will take on the Detroit Lions at 4:05 p.m. ET on Sunday at Empower Field at Mile High. The Broncos are 6-6 overall and 3-3 at home, while Detroit is 1-10-1 overall and 0-5-1 on the road. 

Denver is favored by 10.5 points in the latest Broncos vs. Lions odds from Caesars Sportsbook, and the over-under is set at 42. Before you make any Lions vs. Broncos picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 14 of the 2021 season on an incredible 132-94 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

Now, it has simulated Broncos vs. Lions 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins Broncos vs. Lions? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!