The Week 15 NFL schedule features a cross-conference matchup between teams looking to close out disappointing seasons with the Denver Broncos (3-10) hosting the Arizona Cardinals (4-9) at Empower Field at Mile High in Denver. Both teams will be turning to their backup quarterbacks with Russell Wilson (concussion) expected to be out of action this week and Kyler Murray (knee) out for the season. Denver is looking to snap a five-game winning streak after falling to the Kansas City Chiefs 34-28, while Arizona is out to end a three-game skid after losing 27-13 to the New England Patriots on Monday Night Football. The Broncos are 5-8 against the spread and the Cardinals are 6-7 ATS in 2022.

Kickoff is at 4:05 p.m. ET. Denver is favored by 1.5 points in the latest Broncos vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 37. Before making any Cardinals vs. Broncos picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks. The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Cardinals vs. Broncos 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that hits more than 50% of the time. You absolutely need to see it before locking in your own picks.

So who wins Broncos vs. Cardinals? And which side of the spread hits more than 50 of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.