The Buffalo Bills will take on the Tennessee Titans at 8:15 p.m. ET on Monday Night Football. Buffalo is favored by six points at Caesars Sportsbook, while the Over-Under is 53.5. Before making any Bills vs. Titans picks, you NEED to check out the NFL predictions from the SportsLine Projection Model..

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows the Bills have the best offense in the NFL and the league's best point differential. Buffalo has outscored opponents by 108 points in only five games, with 34.4 points per game and 2.86 points per possession. The Bills take care of the ball, committing only two turnovers, and Buffalo is No. 6 in the NFL in first downs. Defensively, Buffalo is also No. 1 in keeping points off the scoreboard, and the Bills were dominant in a win over Kansas City last week.

The model also knows the Titans are a strong offensive team. Tennessee ranks in the top 10 in points per game (26.4), and the Titans are averaging 2.23 points per offensive possession. The Titans are also in the top 10 in total yardage (389.2 per game) and have a bevy of skill players. Derrick Henry is the team's offensive centerpiece, leading the NFL in rushing yards and rushing touchdowns.

Now, it has set its sights on Bills vs. Titans. We can tell you the model is leaning under the total, and it also says one side of the spread hits in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Bills vs. Titans on Monday Night Football? And which side of the spread cashes in well over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Bills vs. Titans spread you should be all over Monday, all from the model on a 125-83 roll on NFL picks!