Two division leaders and Super Bowl contenders in the AFC will collide when the Buffalo Bills visit the Tennessee Titans for a high-caliber Monday Night Football game. The Bills (4-1) have established themselves as the team to beat in the AFC after a decisive victory over the reigning AFC champion Kansas City Chiefs last Sunday.

Kickoff is set for 8:15 p.m. ET. Buffalo is a six-point favorite in the latest Bills vs. Titans odds from Caesars Sportsbook, and the Over/Under for total points scored is 53.5. 

Before you make any Titans vs. Bills picks or any other NFL predictions, you need to see what SportsLine senior analyst and Tennessee expert Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. This season he has been on fire. Through five weeks Hartstein is 21-7-1 with his NFL picks, for a winning percentage of 75.0 and a profit of $1,305. With his last 26 picks, he is an absurd 21-5.

He also has had a keen eye for the tendencies of the Titans, posting an incredible 20-7-1 record (+1257) on his last 28 spread picks involving Tennessee. Anyone who has consistently followed him is way up.

The Bills lead the league in scoring defense (12.8 points per game) and total defense (251.8 yards per game) and rank second in passing defense (173.4 yards per game). Last week, they limited the high-scoring Chiefs to just 20 points and 392 yards, well below their season averages.

Tennessee running back Derrick Henry has been his usual unstoppable self to start the season. The power back leads the league in rushing yards per game (128.0) and is tied for the league lead in total touchdowns (seven). He is on pace to shatter the NFL's single-season records for rushing yards, rushing attempts and single-season scrimmage touches.

Now, Hartstein has locked in another confident against-the-spread pick for Bills vs. Titans. We can tell you he's leaning Over the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Bills vs. Titans? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Titans vs. Bills spread to jump on, all from the expert who's an outstanding 20-7-1 with his last 28 Titans picks!