The Los Angeles Rams will begin the defense of their Super Bowl title when they host the Buffalo Bills in the 2022 NFL Kickoff Game. Kickoff is set for 8:20 p.m. ET on Thursday, Sept. 8, from SoFi Stadium in Los Angeles. The Bills are 2.5-point favorites and the over-under for total points scored is 53 in the latest Bills vs. Rams odds from Caesars Sportsbook.

Before making any Bills vs. Rams picks or any other 2022 NFL Week 1 predictions, you NEED to see what football expert R.J. White has to say. 

White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine's No. 1 NFL expert in picks against the spread, and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone a whopping 44-33 on his NFL picks involving the Rams, meaning he's well-qualified to pick the 2022 opener.

He's well-known for cashing out big in the Westgate Las Vegas SuperContest twice since 2015. White also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor as the NFL rushing leader at 10-1. Anyone who has followed him is WAY UP!

We can tell you that White is leaning toward the over 53 combined points, but also has isolated an X-factor that has inspired a confident against-the-spread pick! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Bills vs. Rams in the 2022 NFL Kickoff Game? And what critical X-Factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Bills vs. Rams spread to jump on, all from the expert who's 44-33 on Rams picks!