The Buffalo Bills will face the Los Angeles Chargers in a Week 16 game on Saturday at SoFi Stadium. After starting the season 5-5, the Bills (8-6) have won three of four, including their last two. The Chargers (5-9) have been one of the most disappointing teams in the NFL this season and will be playing their first game after the firing of coach Brandon Staley.

Kickoff is scheduled for 8 p.m. ET. Buffalo is a 12-point favorite in the latest Bills vs. Chargers odds while the over/under for total points scored is 44.5. Before you make any Chargers vs. Bills picks or NFL predictions, you need to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model knows that Buffalo's James Cook has been one of the best running backs in the league this season. The second-year back from Georgia ranks second in the NFL in rushing yards (968), behind only Christian McCaffrey. Cook is coming off his best-ever game, rushing for a career-high 179 yards and one touchdown in the 31-10 blowout of the Cowboys.

The model also has taken into account that Los Angeles' Khalil Mack remains an elite pass-rushing force. The 32-year-old former NFL Defensive Player of the Year is tied for third in the league in sacks (15.0) and tied for second in forced fumbles (five). He also has 18 tackles for loss and eight passes defended.

Now, the model has set its sights on Bills vs. Chargers. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in more than 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins Chargers vs. Bills on Saturday? And which side of the spread cashes more than 50% of the time? Join SportsLine now to see which side of the Bills vs. Chargers spread to back, all from the model on an incredible 178-129 run!