Week 10 of the NFL schedule begins with Thursday Night Football as the Chicago Bears host the Carolina Panthers at Soldier Field. The Bears (2-7) sit in last place in the NFC North standings. They have lost two in a row, both on the road. The Panthers (1-7) occupy the basement in the NFC South standings and are one of two one-win teams in the league, along with the Cardinals (1-8). Kickoff is scheduled for 8:15 p.m. ET. Chicago is a 3.5-point favorite in the latest Bears vs. Panthers odds while the over/under for total points scored is 38.

Before you make any Panthers vs. Bears picks or NFL predictions, you need to see what SportsLine senior analyst Larry Hartstein has to say, considering his mastery of picks involving Carolina.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 against-the-spread. Those selections form the basis of his SportsLine NFL best bets, which are 52-37-1 ATS since the start of last season.

Hartstein also has a read on the pulse of the Panthers. In fact, he is 18-8 (+922) in his last 26 picks involving Carolina!

Hartstein knows that Chicago's T.J. Edwards has been a tackling machine this season. The former Eagles linebacker ranks second in the league in tackles (100), behind only the Colts' Zaire Franklin (102). The tackle total is the most by a Bears player through nine games in franchise history.

Hartstein also has taken into account that Carolina receiver Adam Thielen is on pace to have one of the most prolific pass-catching seasons in league history. The former Vikings wideout has 62 receptions over the first eight games this season. He is on pace to have 132 receptions, which would be the sixth highest total in NFL history.

Now, Hartstein has locked in another confident against-the-spread pick for Bears vs. Panthers. We can tell you he's leaning Under the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Bears vs. Panthers on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Panthers vs. Bears spread to jump on, all from the expert who's an outstanding 18-8 on his last 26 picks involving Carolina!