The Baltimore Orioles will look to win their third consecutive game over the Houston Astros when they meet in the fourth and final game of their series on Sunday Night Baseball. After losing 6-0 on Thursday, Baltimore posted a 7-5 win on Friday and 3-2 triumph on Saturday.

First pitch is scheduled for 7:10 p.m. ET from Oriole Park at Camden Yards in Baltimore. The Orioles are the -111 money-line favorites (risk $111 to win $100) in the latest Astros vs. Orioles odds, while the Astros are -108 underdogs. The over/under for total runs scored is 8 in the latest MLB odds via SportsLine consensus. 

Before you make any Astros vs. Orioles picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 21 of the 2024 MLB season on a 25-13 roll on top-rated run-line picks (+732). Anybody following has seen STRONG returns!

The model knows Astros second baseman Jose Altuve, a 12-year veteran, is among the team leaders in hitting at .299 with 22 doubles, 17 homers, 55 RBI and 73 runs scored. He has hits in seven of the past eight games, including two in a row. In a 2-0 win over the Chicago White Sox on Aug. 18, he was 2-for-3 with a homer. He is 3-for-11 in the series against Baltimore with two homers and three RBI.

The model also knows shortstop Gunnar Henderson is among the Orioles' top hitters. The third-year veteran has hits in seven of the past 10 games, including a 2-for-4 performance with a home run in a 5-1 loss to the Boston Red Sox on Aug. 17. In 129 games this season, he is batting .284 with 24 doubles, six triples, 33 homers, 78 RBI and 101 runs scored. In 15 career games against Houston, he has homered twice with four RBI.

The model has simulated Astros vs. Orioles 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Astros vs. Orioles, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 25-13 roll on top-rated MLB run-line picks!