Head coach Deion Sanders and the Colorado Buffaloes (4-5, 1-5 Pac-12) will be looking to snap a three-game losing streak when they host the No. 21 Arizona Wildcats (6-3, 4-2 Pac-12) at Folsom Field on Saturday. Kickoff in Boulder is scheduled for 2 p.m. ET. The Buffs are coming off a 26-19 loss to Oregon State where quarterback Shedeur Sanders threw two touchdown passes, but was sacked four times. The Wildcats are looking to stay alive in the Pac-12 race and build off an impressive 27-10 win over UCLA. Arizona is 7-1, while CU is 5-3-1 against the spread in 2023. Former NFL coach Pat Shurmur will once again call the offensive plays for the Buffs

The Wildcats are 9.5-point favorites in the latest Colorado vs. Arizona odds via SportsLine consensus, while the over/under for total points scored is 54.5. Arizona is a -364 (risk $364 to win $100) favorite on the money line, with Colorado listed at +283 (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Colorado vs. Arizona picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, including a 5-1 mark in the CU vs. USC game. He's also 51-22-2 on all of his CFB best bets this season so far! Anyone who has followed his picks is WAY UP!

Kaylor knows the Buffs are reeling after getting off to a hot start to the 2023 season. The Buffs have lost, but covered in their last two contests and quarterback Shedeur Sanders continues to get hit and sacked at an alarming rate. Former NFL head coach Pat Shurmur will once again be calling the plays for Colorado's offense against Arizona.

Kaylor, however, also factored in that Oregon State is coming off a highly disappointing loss to an unranked opponent in Arizona. The Beavers have one of the top rushing attacks in the Pac-12, averaging 187.1 yards per game. They will be facing a Colorado defense that gives up 165 yards per game on the ground.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Arizona. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Colorado vs. Arizona in the Buffs' first game against the Wildcats under coach Deion Sanders on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Arizona vs. Colorado spread to jump on, all from the expert who is on a 51-22 roll on his college football picks this season, and find out!