Head coach Deion Sanders and the Colorado Buffaloes (3-2) look to bounce back from 48-41 loss to No. 9 USC when they travel to the desert to take on the Arizona State Sun Devils (1-4) on Saturday. The Buffs got down big early to Caleb Williams and the Trojans, but Shedeur Sanders led an impressive comeback in the second half to finish the game within one score. The Sun Devils are coming off a hard-fought 24-21 loss to Cal. Two-way star Travis Hunter (liver) remains out, while safety Shilo Sanders remains questionable for Colorado. The Buffs are 3-2 against the spread under Coach Prime.

The Buffaloes are 3-point favorites in the latest Colorado vs. Arizona State odds via SportsLine consensus, while the over/under for total points scored is 58.5 and Colorado is a -159 favorite on the money line. (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Colorado vs. Arizona State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, going 11-3 on his best bets in the Buffs' first five games, including a 5-1 mark in the CU vs. USC game. He's also 18-3 on all his CFB best bets this season so far! Anyone who has followed his picks is WAY UP!

Kaylor knows that some weaknesses in the Buffs' roster have been exposed over the past three weeks in their games with Colorado State, Oregon, and USC. CU allows 480.2 yards per game to opposing offenses, and they are one of the most sacked teams in all of college football. He's also considered that junior quarterback Shedeur Sanders is one of the best players in the country. Sanders remains a Heisman Trophy contender and was outstanding in the second half against USC.

Kaylor, however, also factored in that Arizona State is a difficult place to play. The Sun Devils will have added motivation as home underdogs with the Deion Sanders hype train coming to town. He has seen that Arizona State is a team that has improved every week, even if its win/loss record doesn't reflect that.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Arizona State. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Colorado vs. Arizona State in the Buffs' first game against the Sun Devils under Deion Sanders on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Arizona State vs. Colorado spread to jump on, all from the expert who is on a 11-3 roll betting on Colorado games this season, and find out!