The Appalachian State Mountaineers visit the Louisiana Ragin' Cajuns in a high-profile midweek battle at 7:30 p.m. ET on Tuesday. Appalachian State is favored by 4.5 points at Caesars Sportsbook, while the Over-Under is set at 57 (see up-to-date odds for every game this week on our college football odds page).

Before making any Appalachian State vs. Louisiana picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Appalachian State is a potent offensive team in 2021. The Mountaineers are No. 2 in the Sun Belt in both scoring offense (35.2 points per game) and total offense (more than 480 yards per game), and Appalachian State is generating 6.5 yards per play offensively. The Mountaineers are completing nearly 68 percent of passes with a yards-per-attempt average of 8.8, and Appalachian State has allowed only five sacks in five games.

The model also knows Louisiana is very good offensively in their own right. The Ragin' Cajuns are averaging nearly 400 total yards of offensive per game and putting up more than 28 points per game. Balance is a theme for Louisiana, with three different rushers eclipsing 230 yards this season, and the Ragin' Cajuns have completed multiple passes to 12 different receivers in 2021.

Now, it has set its sights on Appalachian State vs. Louisiana. We can tell you the model is leaning under the total, and it also says one side of the spread hits in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Appalachian State vs. Louisiana? And which side of the spread hits in well over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Appalachian State vs. Louisiana spread you should be all over Tuesday, all from the model on a roll on college football picks!