The Appalachian State Mountaineers will take on the East Carolina Pirates at 7:30 p.m. ET on Thursday at Bank of America Stadium. The Mountaineers ended last year with a 9-3 record, while East Carolina finished eighth in the American Athletic. The Mountaineers are favored by 10-points in the latest Appalachian State vs. East Carolina odds from Caesars Sportsbook, and the over-under is set at 56. 

Before you make any East Carolina vs. Appalachian State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Appalachian State vs. East Carolina 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Appalachian State vs. East Carolina? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.