The Houston Astros and Boston Red Sox meet in an American League Championship Series Game 5 matchup on Wednesday. Houston rallied for a 9-2 win on Tuesday to tie the series 2-2. First pitch from Fenway Park in Boston is set for 5:08 p.m. ET. Boston is the -125 favorite (risk $125 to win $100) on the money line in the latest Astros vs. Red Sox odds from Caesars Sportsbook, while the over-under for total runs scored is nine.

Before making any Astros vs. Red Sox picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters the third week of the 2021 MLB playoffs with a 207-176 record on top-rated MLB money-line picks, returning well over $600. Anyone following it has seen some HUGE returns!

The model knows shortstop Xander Bogaerts has been red hot in the postseason and was Boston's lone bright spot in Game 4. Bogaerts finished 2-for-5 with a homer, two RBIs and a run scored. He is 5-for-18 (.278) in the series. In nine postseason games, he is 12-for-38 (.316) with two doubles, three home runs and six RBIs. He is hitting .256 against Houston in 11 games this year, and is 57-for-185 (.308) in 47 career games against the Astros.

The model also knows Astros outfielder Michael Brantley has been dominant this postseason with hits in seven of eight games, including three multi-hit performances, and is batting .306. He helped fuel the Astros' seven-run ninth inning on Tuesday and was 2-for-5 with a double, three RBIs and one run scored. He finished the regular season with a .311 batting average with eight homers, 47 RBIs and 68 runs scored. Brantley has pounded Boston pitching throughout his career and is batting .319 against them in 55 games, including 18 doubles, three homers and 27 RBIs.

Now, it has set its sights on Astros vs. Red Sox. We can tell you it's leaning Over on the total, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Astros vs. Red Sox in Game 5 of their American League Championship Series on Wednesday? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Astros vs. Red Sox money line you should be all over on Wednesday, all from the model that is crushing its MLB picks in 2021!