The Penn State Nittany Lions will take on the No. 15 Virginia Tech Hokies at 9 p.m. ET on Tuesday at Cassell Coliseum. The Hokies are favored by 5 points in the latest Virginia Tech vs. Penn State odds from William Hill Sportsbook, and the Over-Under is set at 141.5. Before you make any Penn State vs. Virginia Tech picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,700 for $100 players on its top-rated college basketball picks against the spread. It's also off to a fast start in the 2020-21 season, going 5-1 on all its top-rated picks and returning over $400. Anyone who has followed it has seen huge returns.

Now, it has simulated Virginia Tech vs. Penn State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Virginia Tech vs. Penn State? And which side of the spread is hitting in over 50 percent of simulations? ... Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.