The Philadelphia 76ers will take on the Portland Trail Blazers at 7 p.m. ET on Monday at Wells Fargo Center. The Sixers are 4-2 overall and 2-1 at home, while Portland is 3-3 overall and 0-2 on the road. Philadelphia is ranked second in the Atlantic Division; the Trail Blazers are ranked fourth in the Northwest Division. 

Philadelphia is favored by six points in the latest 76ers vs. Trail Blazers odds from Caesars Sportsbook, and the over-under is set at 220.5. 

Before making any Sixers vs. Blazers picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model finished up almost $600 on its top-rated picks last season and enters Week 2 of the 2021-22 NBA season on a stunning 103-68 roll on top-rated NBA picks against the spread. Anyone following it has seen huge returns.

Now, it has simulated 76ers vs. Trail Blazers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins 76ers vs. Trail Blazers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks..