The San Francisco 49ers will continue their surge toward the postseason when they visit the Tennessee Titans on Thursday Night Football. San Francisco (8-6) has bounced back from a 3-5 start to the 2021 NFL season by winning five of its last six contests, while Tennessee (9-5) has lost three of its last four.

Kickoff from Nissan Stadium is set for 8:20 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Titans odds from Caesars Sportsbook, while the over-under for total points scored is 45. Before making any Titans vs. 49ers picks, you NEED to see which side SportsLine expert Larry Hartstein is on.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2021 campaign, Hartstein was 351-291 all-time on NFL sides, returning more than $2,200 for $100 bettors. 

In addition, Hartstein is an expert on the Titans. He is a blistering 21-10-1 in his last 32 against-the-spread picks involving Tennessee, returning more than $1,000 for $100 bettors. Anyone who has followed him is way up.

San Francisco is coming off a 31-13 win over Atlanta last Sunday in which it outgained the Falcons 162-62 on the ground. Playing in just his fifth game of the season, Jeff Wilson led the attack with 110 yards and a touchdown on 21 carries, while Deebo Samuel and Kyle Juszczyk also ran for scores. Samuel is among the top receivers in the NFL with 1,088 yards and leads the 49ers with seven rushing TDs.

Tennessee has gone 3-3 since losing 2020 NFL rushing leader Derrick Henry to a fractured foot, but has received 100-yard rushing performances from two different running backs over its last three games. Dontrell Hilliard (131 yards) and D'Onta Foreman (109) both reached triple-digit rushing yards in the Titans' loss at New England in Week 12, while the latter rushed for 108 in Sunday's 19-13 setback at Pittsburgh. Tennessee had a 201-35 advantage in rushing yards against the Steelers and owned a 13-3 lead at halftime.

Now, Hartstein has locked in another confident against-the-spread pick for 49ers vs. Titans. We can tell you he's leaning Over, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins 49ers vs. Titans on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Titans vs. 49ers spread to jump on, all from the expert who's an outstanding 21-10 on picks involving Tennessee!