The San Francisco 49ers, owners of home field advantage in the NFC Playoffs, host the Los Angeles Rams, who are also playoff bound, on Sunday afternoon. San Francisco (12-4) enters off a 27-10 win at Washington, while Los Angeles (9-7) clinched a playoff spot with a 26-25 win at the New York Giants in Week 17. The 49ers have won nine of the last 10 meetings, including a 30-23 victory in Week 2.

Kickoff is set for 4:25 p.m. ET at Levi's Stadium. The 49ers are favored by 4 points in the latest San Francisco vs. Los Angeles odds, while the over/under is 40 points per SportsLine consensus. Before entering any Rams vs. 49ers picks, you NEED to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 of the 2023 NFL season on an incredible 181-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 35-21 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated Rams vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also says one side of the spread hits more than 50% of the time!

So who wins 49ers vs. Rams, and which side of the spread hits in more than 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!