A star-studded showdown is set to get underway on Sunday when the Jacksonville Jaguars host the San Francisco 49ers. San Francisco (5-3) enters off a bye after falling to Cincinnati, 31-17, in Week 8. Jacksonville (6-2) also was off in Week 9 but enters on a five-game winning streak after defeating Pittsburgh, 20-10. The 49ers won the most recent matchup, 30-10, in 2021.

Kickoff from EverBank Stadium is set for 1 p.m. ET. San Francisco is a 3-point favorite in the 49ers vs. Jaguars odds via SportsLine consensus, while the over/under is 45. Before making any San Francisco vs. Jacksonville picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2023 NFL season on an incredible 174-123 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 28-15 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Jaguars vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Under the total, and it also says one side of the spread is the better value! You ABSOLUTELY need to see it before locking in your own picks. 

Who wins Jaguars vs. 49ers, and which side of the spread is the better value? Join SportsLine right now to find out which side of the 49ers-Jaguars spread is a MUST-BACK, all from the model on a 174-123 roll on NFL picks!