The San Francisco 49ers (2-0) will seek their 13th consecutive regular-season win when they host the New York Giants (1-1) on Thursday Night Football. San Francisco has road wins against Pittsburgh and the Los Angeles Rams this season, scoring 30 points in both contests. New York avoided an 0-2 start to the year by staging the franchise's largest comeback of the Super Bowl era last Sunday to post a 31-28 win at Arizona, but will be without running back Saquon Barkley (ankle).

Kickoff at Levi's Stadium is set for 8:15 p.m. ET. San Francisco is a 10.5-point favorite in the latest 49ers vs. Giants odds, while the over/under for total points scored is 44. Before making any Giants vs. 49ers picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2023 NFL season on an incredible 164-117 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 18-9 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows San Francisco trailed Los Angeles late in the second quarter last Sunday before outscoring the Rams 20-6 en route to victory. Christian McCaffrey came up with another strong effort on the ground, as he carried 20 times for 116 yards and a touchdown. Dating back to last season, the 27-year-old has recorded five 100-yard rushing performances in his last seven games and run for a TD in six of them.

The model also knows New York was outscored 60-0 over its first six quarters of the season and was behind 28-7 late in the third quarter against Arizona before coming alive. Quarterback Daniel Jones completed 81% of his attempts in the second half and finished with 321 passing yards and two touchdowns while also running for 59 yards and a score.

Now, the model has set its sights on 49ers vs. Giants on Thursday Night Football. We can tell you the model is leaning Over the total, and it also says one side of the spread cashes in almost 60% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins 49ers vs. Giants on Thursday Night Football? And which side of the spread cashes almost 60% of the time? Join SportsLine now to see which side of the Giants vs. 49ers spread to back, all from the model that's an amazing 164-117 on NFL picks!