One team will start the season 2-0 when the Philadelphia Eagles host the San Francisco 49ers on Sunday at Lincoln Financial Field. Kickoff is 1 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Eagles odds from Caesars Sportsbook while the Over/Under for total points scored is 49. (See the latest NFL lines for every game this week on our NFL odds page.)

Before you make any Eagles vs. 49ers picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model.

The model, The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model knows that the San Francisco offense is coming off one of its best performances in a while. The 49ers scored 31 points in the first half against the Lions on Sunday, the most they've scored in a first half since scoring 35 against the Rams in 2008.

The model also knows that Philadelphia quarterback Jalen Hurts is coming off his best passing performance as a pro. In the win over the Falcons, the second-year quarterback had a passer rating of 126.4 after going 27-of-35 for 264 yards and three touchdowns. That's the highest passer rating by an Eagle since Carson Wentz (128.3 rating) in Week 5 of 2017.

Now, the model has set its sights on 49ers vs. Eagles. We can tell you it's leaning Under the total, and it also says one side of the spread has ALL the value! You ABSOLUTELY need to see it before locking in any NFL picks of your own.

So who wins Eagles vs. 49ers on Sunday? And which side of the spread has ALL the value? ... Join SportsLine right now to find out which side of the 49ers vs. Eagles spread you should be all over, all from the advanced model that has returned almost $7,900 on top-rated NFL picks!