After two days of intense joint practices, the San Francisco 49ers and Los Angeles Chargers will square off Sunday night in a Week 2 preseason matchup at SoFi Stadium. Kickoff is set for 7:30 p.m. ET. The 49ers are 5.5-point favorites in the latest 49ers vs. Chargers odds from Caesars Sportsbook, while the Over-Under is 34.

Before you make your 49ers vs. Chargers picks or any other NFL predictions, you MUST see what San Francisco expert Tom Fornelli has to say. 

The CBS national writer went a profitable 31-22 last season on his NFL best bets. What's more, he has demonstrated a particularly sharp eye for the 49ers. In fact, Fornelli has gone a stunning 14-6 on picks involving San Francisco. Anyone who has followed him is WAY UP.

The competition between quarterbacks Jimmy Garoppolo and rookie Trey Lance should be an advantage for the 49ers as they press to impress the coaches. Garoppolo is trying to redeem himself after an injury-plagued year, while Lance is pushing to become the starter as soon as he can. San Francisco put up 383 yards in its preseason opener, but lost to reigning AFC champion Kansas City 19-16.

Chargers fans likely won't see quarterback Justin Herbert, who threw for 4,336 yards and 31 touchdowns in 15 starts last season. Los Angeles' pass rush could also wreak havoc against a Niners team that yielded five sacks last week. The Chargers allowed just 147 passing yards in a 13-6 victory against the Rams in their preseason kickoff last Saturday.       

For 49ers vs. Chargers, we can tell you that Fornelli is leaning Under the total, but his much stronger play is on the spread. In fact, Fornelli has found a crucial X-factor that has him going BIG on one side! You ABSOLUTELY need to see it before locking in your own picks.

Who wins 49ers vs. Chargers? And which crucial X-factor makes one side of the spread hit hard? ... Join SportsLine right now to see which side of the 49ers vs. Chargers spread to jump on Sunday, all from the expert who's 14-6 on Niners picks!