The San Francisco 49ers (1-1) and Denver Broncos (1-1) clash on Sunday Night Football. Kickoff is set for 8:20 p.m. ET from Empower Field. San Francisco is a 1.5-point favorite in the latest 49ers vs. Broncos odds from Caesars Sportsbook, and the over/under for total points scored is 45. Before you make any 49ers vs. Broncos picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model knows San Francisco will look to get its powerful rushing attack going. Kyle Shanahan loves to build his passing game based on an effective ground game. The Niners currently rank fourth in the league in rushing yards per game (182.5) with three touchdowns. In the win over the Seattle Seahawks last week, they ran for 183 yards on 4.2 yards per rush. 

The model also knows Denver is looking to get more rhythm on offense. Through two weeks, Denver ranks eighth in passing yards per game (265.5). Receiver Courtland Sutton is a big-bodied weapon on the outside who can bring down contested balls. Last week, he finished with seven catches for 122 yards. 

Now, it has set its sights on 49ers vs. Broncos on Sunday Night Football. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins Broncos vs. 49ers on Sunday Night Football? And which side of the spread hits over 50% of the time? Join SportsLine now to see which side of the Broncos vs. 49ers spread to back, all from the model that 's an amazing 139-102 on NFL picks!